-
Jan 17, 2025 | 
nature.com | Francisco J. Quintana
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites prevent infection-triggered immunopathology by activating the aryl hydrocarbon receptor; pathogens inhibit this protective mechanism.
-
Dec 20, 2024 | 
nature.com | Francisco J. Quintana
Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis.
-
Aug 18, 2024 | 
nature.com | Francisco J. Quintana
Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.
-
Jun 21, 2024 | 
nature.com | Francisco J. Quintana
Astrocytes have important roles in the repair of the CNS. However, the underlying mechanisms involved remain incompletely understood. O’Shea et al. report that the functional reprogramming of astrocytes at the borders of traumatic lesions contributes to the re-establishment of CNS integrity by separating the parenchyma from stromal and immune cells.
-
Mar 15, 2024 | 
thenewstack.io | Tomasz Grabiec |Darryl Taft |Francisco J. Quintana |Heather Joslyn
Fly.io is behind what may be one of the hottest underground developer movements happening today, as the company has quietly attracted more than a quarter-million developers organically and is now establishing key partnerships to reach even more devs. Fly.io is a platform for developers to easily launch and manage applications globally. Kurt Mackey, CEO and founder of Fly.io, said.
-
Mar 15, 2024 | 
thenewstack.io | Francisco J. Quintana |Charles Xie |Luis Ceze |Christina Lin
In my almost 10 years as a data science and artificial intelligence (AI) expert, I’ve witnessed the evolution of AI up close. Like many people, I have been told that eventually my job will become obsolete because AI will replace me. While I never believed this previously, global organizations increasingly trust important tasks to AI, and media speculation is growing that AI will take over the world. AI has existed since the 1950s, so it’s nothing new.
-
Feb 15, 2024 | 
thenewstack.io | Tomasz Grabiec |Janakiram MSV |Charles Humble |Francisco J. Quintana
In the first article in this series, I discussed the three paradoxes of cloud native platform engineering: how measuring developer productivity can inadvertently lower it; how platform-engineering efforts can backfire by being overly normative; and how cloud native developers must focus on individual microservices as well as the behavior of pods and clusters simultaneously.
-
Jan 22, 2024 | 
lanacion.com.ar | Francisco J. Quintana
Los obstáculos que surgen para imposibilitar la manda constitucional de transferencia de la Justicia nacional a la Ciudad Autónoma de Buenos Aires no representan una novedad.
-
Dec 12, 2023 | 
nature.com | Francisco J. Quintana
AbstractThe development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet clinical need for the management of autoimmunity, allergy, organ transplantation and gene therapy. Recent breakthroughs in our understanding of immune tolerance mechanisms have opened new research avenues and therapeutic opportunities in this area. Here, we review mechanisms of immune tolerance and novel methods for its therapeutic induction.
-
Sep 12, 2023 | 00369-2&sz=64)
cell.com | Michael Wheeler |Francisco J. Quintana
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
