
Francisco J. Quintana
Articles
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5 days ago |
jci.org | Carolina M. Polonio |Francisco J. Quintana |Jessica Wei |Pierre-Paul Axisa
AbstractB cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes.
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1 month ago |
nature.com | Jinsu Lee |Camilo Faust Akl |Michael Kilian |Sharmin Ghaznavi |Stelios M. Smirnakis |Isaac M. Chiu | +3 more
AbstractNeuroimmune interactions—signals transmitted between immune and brain cells—regulate many aspects of tissue physiology1, including responses to psychological stress2,3,4,5, which can predispose individuals to develop neuropsychiatric diseases6,7,8,9. Still, the interactions between haematopoietic and brain-resident cells that influence complex behaviours are poorly understood.
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Jan 17, 2025 |
nature.com | Francisco J. Quintana
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites prevent infection-triggered immunopathology by activating the aryl hydrocarbon receptor; pathogens inhibit this protective mechanism.
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Dec 20, 2024 |
nature.com | Francisco J. Quintana
Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis.
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Aug 18, 2024 |
nature.com | Francisco J. Quintana
Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.
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