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3 weeks ago | 
jci.org | Carolina M. Polonio |Francisco J. Quintana |Jessica Wei |Pierre-Paul Axisa
AbstractB cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes.
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2 months ago | 
nature.com | Jinsu Lee |Camilo Faust Akl |Michael Kilian |Sharmin Ghaznavi |Stelios M. Smirnakis |Isaac M. Chiu | +3 more
AbstractNeuroimmune interactions—signals transmitted between immune and brain cells—regulate many aspects of tissue physiology1, including responses to psychological stress2,3,4,5, which can predispose individuals to develop neuropsychiatric diseases6,7,8,9. Still, the interactions between haematopoietic and brain-resident cells that influence complex behaviours are poorly understood.
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Jan 17, 2025 | 
nature.com | Francisco J. Quintana
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites prevent infection-triggered immunopathology by activating the aryl hydrocarbon receptor; pathogens inhibit this protective mechanism.
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Dec 20, 2024 | 
nature.com | Francisco J. Quintana
Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis.
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Aug 18, 2024 | 
nature.com | Francisco J. Quintana
Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.
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Jun 21, 2024 | 
nature.com | Francisco J. Quintana
Astrocytes have important roles in the repair of the CNS. However, the underlying mechanisms involved remain incompletely understood. O’Shea et al. report that the functional reprogramming of astrocytes at the borders of traumatic lesions contributes to the re-establishment of CNS integrity by separating the parenchyma from stromal and immune cells.
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Mar 15, 2024 | 
thenewstack.io | Tomasz Grabiec |Darryl Taft |Francisco J. Quintana |Heather Joslyn
Fly.io is behind what may be one of the hottest underground developer movements happening today, as the company has quietly attracted more than a quarter-million developers organically and is now establishing key partnerships to reach even more devs. Fly.io is a platform for developers to easily launch and manage applications globally. Kurt Mackey, CEO and founder of Fly.io, said.
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Mar 15, 2024 | 
thenewstack.io | Francisco J. Quintana |Charles Xie |Luis Ceze |Christina Lin
In my almost 10 years as a data science and artificial intelligence (AI) expert, I’ve witnessed the evolution of AI up close. Like many people, I have been told that eventually my job will become obsolete because AI will replace me. While I never believed this previously, global organizations increasingly trust important tasks to AI, and media speculation is growing that AI will take over the world. AI has existed since the 1950s, so it’s nothing new.
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Feb 15, 2024 | 
thenewstack.io | Tomasz Grabiec |Janakiram MSV |Charles Humble |Francisco J. Quintana
In the first article in this series, I discussed the three paradoxes of cloud native platform engineering: how measuring developer productivity can inadvertently lower it; how platform-engineering efforts can backfire by being overly normative; and how cloud native developers must focus on individual microservices as well as the behavior of pods and clusters simultaneously.
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Jan 22, 2024 | 
lanacion.com.ar | Francisco J. Quintana
Los obstáculos que surgen para imposibilitar la manda constitucional de transferencia de la Justicia nacional a la Ciudad Autónoma de Buenos Aires no representan una novedad.
