Carolina R. DaSilva

Nov 14, 2023 | nature.com | Rachel M. Wigmore |Anne Kennedy |Carolina R. DaSilva |Jialing Huang |Gerald J. O’Connor |Miao Cao | +4 more

AbstractEnvironmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of colonic FOXP3+ regulatory T (Treg) cells and local immune homeostasis.