Miao Cao

2 months ago | nature.com | Qingyang Li |Miao Cao |Dan Stein |Barbara Sahakian |Tianye Jia |Christelle Langley | +22 more

AbstractLaboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.

Nov 14, 2023 | nature.com | Rachel M. Wigmore |Anne Kennedy |Carolina R. DaSilva |Jialing Huang |Gerald J. O’Connor |Miao Cao | +4 more

AbstractEnvironmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of colonic FOXP3+ regulatory T (Treg) cells and local immune homeostasis.