Caroline Seydel

California

Science writer covering genetics, cancer, biotech. "Truth is a matter of the imagination. The soundest fact may fail or prevail in the style of its telling."

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Articles

Beyond cell atlases: spatial biology reveals mechanisms behind disease - Nature Biotechnology

2 weeks ago | nature.com | Caroline Seydel

As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research. You have full access to this article via your institution. To deeply investigate cell–cell interactions, particularly at the frontiers of disease, researchers increasingly are turning to spatial biology.
Crossing the Cell Membrane Without Viruses

3 weeks ago | genengnews.com | Caroline Seydel |Kathy Vuksanaj

Home Topics Drug Discovery Crossing the Cell Membrane Without Viruses Because their gene editing platform is entirely based on RNA, Tessera Therapeutics can use lipid nanoparticles (LNPs) for delivery to the cells of interest. LNPs are less immunogenic and less expensive to manufacure than viruses. Because their gene editing platform is entirely based on RNA, Tessera Therapeutics can use lipid nanoparticles (LNPs) for delivery to the cells of interest.
The Emotional Impact of Cancer and Loss, in Your Own Words: Survey Results

2 months ago | patientpower.info | Caroline Seydel

Jump ToNavigating the DiagnosisYour EmotionsManaging EmotionsSharingMedical SupportOver TimeTransformationResourcesCare PartnersClosing ThoughtsReceiving a cancer diagnosis often leads to a surge of strong emotions, including shock, disbelief, anger, and fear. It may be difficult to put into words what you feel, and you might not steadily progress through a set series of emotions. It can be helpful to know that, however you are feeling, there are others out there who feel the same.
Cancer Vaccines Improve Their Aim

2 months ago | genengnews.com | Caroline Seydel

Cancer vaccines have been a tantalizing idea for decades, but the vast complexity of the human immune system has posed significant challenges. Now, technological advances like rapid DNA sequencing, lymph node targeting, and AI-informed antigen selection are enabling the creation of precision vaccines that target cancers effectively while minimizing harmful side effects.
Life beyond labels - Nature Methods

2 months ago | nature.com | Caroline Seydel

Advances in label-free microscopy allow researchers to visualize the invisible in complex biological systems, even living animals, from whole organs down to the tiniest peptides. You have full access to this article via your institution. Part of a complete brain scan dataset from a 69-year-old woman imaged using HiP-CT.
New mRNA Vaccines Target a Host of Viral and Bacterial Pathogens

Mar 3, 2025 | genengnews.com | Caroline Seydel

Home Topics Infectious Diseases New mRNA Vaccines Target a Host of Viral and Bacterial Pathogens Credit: Tumeggy / Science Photo Library / Getty Images Credit: Tumeggy / Science Photo Library / Getty Images In recent years, mRNA technology has come into its own, most prominently in the field of vaccine development.
Gene and Cell Therapies Take Aim at Parkinson’s Disease

Dec 4, 2024 | genengnews.com | Caroline Seydel

Home Topics Drug Discovery Gene and Cell Therapies Take Aim at Parkinson’s Disease Credit: Love Employee / iStock / Getty Images Plus Credit: Love Employee / iStock / Getty Images Plus Parkinson’s disease is characterized by the loss of dopamine-producing neurons. The current treatment is oral levodopa, which is taken up by brain neurons and converted to dopamine. But levodopa eventually loses its efficacy as those neurons continue to die.
Largest-ever genetic study of suicide finds new risk factors

Oct 2, 2023 | medicalxpress.com | Caroline Seydel

The reasons why people attempt suicide are complex and include external triggers like trauma and stress, as well as inherited genetic factors. A new study published online on October 1 in the American Journal of Psychiatry has identified 12 DNA variants, or variations in the human genetic code, that are associated with risk of attempting suicide.
Greening the lab - Nature Methods

Sep 20, 2023 | nature.com | Caroline Seydel

Making biological research more sustainable requires an accurate assessment of its environmental impact, both at the bench and on the computer. Molecular biology is transforming our world in ways that only the wildest dreamers could have imagined fifty years ago. Babies with catastrophic genetic conditions can be diagnosed and treated within days thanks to rapid whole-genome sequencing. CRISPR gene editing has created new, effective treatments for sickle cell disease.
Gene variant may help explain why Black individuals are prone to severe strokes

Jul 24, 2023 | medicalxpress.com | Caroline Seydel

In a new study, University of Utah Health researchers have shown that a particular version of a gene may contribute to the higher severity of stroke seen among Black Americans. The findings could help scientists develop more effective stroke medications for people who carry the gene. The research, which was published in the Journal of Clinical Investigation, demonstrated that mice carrying the gene had a higher level of disability after a stroke.