Carter Grochala

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Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer | Nature Communications

Dec 11, 2023 | nature.com | Carter Grochala |Jennifer L. Guerriero |Gerburg Wulf |Brian Wolpin |Ben Z. Stanger |Andrew J. Aguirre | +1 more

Retraction to: Nature Communications https://doi.org/10.1038/s41467-023-37096-6, published online 13 March 2023RETRACTION NOTEThe Editors retracted this article because of concerns regarding a number of figures presented in this work. These concerns call into question the integrity of the data and the article’s overall scientific soundness.
Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer - Nature Communications

Mar 13, 2023 | nature.com | Jennifer L. Guerriero |Gerburg Wulf |Brian Wolpin |Ben Z. Stanger |Andrew J. Aguirre |Alan D. D’Andrea | +1 more

AbstractRecently developed inhibitors of polymerase theta (POLθ) have demonstrated synthetic lethality in BRCA-deficient tumor models. To examine the contribution of the immune microenvironment to antitumor efficacy, we characterized the effects of POLθ inhibition in immunocompetent models of BRCA1-deficient triple-negative breast cancer (TNBC) or BRCA2-deficient pancreatic ductal adenocarcinoma (PDAC).

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