Ben Z. Stanger

Nov 12, 2024 | nature.com | Alvaro Curiel-Garcia |Margo I Orlen |Clint A. Stalnecker |Julien Dilly |Marie C. Hasselluhn |Stephanie Chang | +16 more

Correction to: Nature https://doi.org/10.1038/s41586-024-07379-z Published online 8 April 2024In the version of the article initially published, in the Data availability section, the GEO accession number was incorrect and has now been amended to GSE252002 in the HTML and PDF version of the article.

Jul 26, 2024 | onlinelibrary.wiley.com | Takeshi Katsuda |Jonathan Sussman |Kenneth S. Zaret |Ben Z. Stanger

INTRODUCTION Pioneer transcription factors (TFs) play a crucial role in cell fate decisions during embryonic development and cellular reprogramming via their unique ability to enact persistent epigenomic changes.[1, 2] The name “pioneer factor” derives from an ability to facilitate chromatin opening; whereas most TFs can bind to regions of chromatin that are already accessible, pioneer factors have an increased ability to bind to DNA regions that are embedded in nucleosomes (“closed...

Apr 8, 2024 | nature.com | Alvaro Curiel-Garcia |Margo I Orlen |Clint A. Stalnecker |Julien Dilly |Marie C. Hasselluhn |Stephanie Chang | +16 more

AbstractBroad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2. RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3.

Dec 11, 2023 | nature.com | Carter Grochala |Jennifer L. Guerriero |Gerburg Wulf |Brian Wolpin |Ben Z. Stanger |Andrew J. Aguirre | +1 more

Retraction to: Nature Communications https://doi.org/10.1038/s41467-023-37096-6, published online 13 March 2023RETRACTION NOTEThe Editors retracted this article because of concerns regarding a number of figures presented in this work. These concerns call into question the integrity of the data and the article’s overall scientific soundness.

Aug 22, 2023 | lithub.com | Ben Z. Stanger

Discovery can be a messy business. Rarely is there a straight line to new knowledge; instead, hypotheses and interpretations must navigate a roundabout and often directionless path. But rather than an obstacle to wisdom, this is better considered a necessary part of the process. We have already seen several instances in which important discoveries came about when researchers abandoned their original ideas, creating bias-​free conditions that fostered new paradigms.