Cassandra L Moyer

Aug 15, 2024 | digitalcommons.library.tmc.edu | Cassandra L Moyer |Amanda Lanier |Jing Qian |Darian Coleman

PURPOSE: Rexinoids, agonists of nuclear retinoid X receptor (RXR), have been used for the treatment of cancers and are well tolerated in both animals and humans. However, the usefulness of rexinoids in treatment of breast cancer remains unknown. This study examines the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action.

Aug 15, 2024 | digitalcommons.library.tmc.edu | Cassandra L Moyer |Powel Brown

AbstractAdvancements in research have led to the steady decline of breast cancer mortality over the past thirty years. However, breast cancer incidence has continued to rise, resulting in an undue burden on healthcare costs and highlighting a great need for more effective breast cancer prevention strategies, including targeted chemo preventative agents.