Darian Coleman

Aug 15, 2024 | digitalcommons.library.tmc.edu | Cassandra L Moyer |Amanda Lanier |Jing Qian |Darian Coleman

PURPOSE: Rexinoids, agonists of nuclear retinoid X receptor (RXR), have been used for the treatment of cancers and are well tolerated in both animals and humans. However, the usefulness of rexinoids in treatment of breast cancer remains unknown. This study examines the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action.