Cathal Ormond

Jul 29, 2024 | nature.com | Tyrone D. Cannon |Patrick Sullivan |Michael Gill |Cathal Ormond |Niamh M. Ryan

AbstractMonozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic discordance and contribute to disease etiology. Here we performed whole genome sequencing in 17 pairs of MZ twins discordant for a psychotic disorder (schizophrenia, schizoaffective disorder or bipolar disorder).