Tyrone D. Cannon

Jul 29, 2024 | nature.com | Tyrone D. Cannon |Patrick Sullivan |Michael Gill |Cathal Ormond |Niamh M. Ryan

AbstractMonozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic discordance and contribute to disease etiology. Here we performed whole genome sequencing in 17 pairs of MZ twins discordant for a psychotic disorder (schizophrenia, schizoaffective disorder or bipolar disorder).

Apr 8, 2024 | onlinelibrary.wiley.com | Tyrone D. Cannon

• , , , , & ( ). Harmonizing the structured interview for psychosis-risk syndromes (SIPS) and the comprehensive assessment of at-risk mental states (CAARMS): An initial approach . Early Intervention in Psychiatry, , – . • , , , , , , , , , , , , , , , & ( ). An individualized risk calculator for research in prodromal psychosis . The American Journal of Psychiatry, ( ), – . https://doi.org/10.1176/appi.ajp.2016.15070890• , , , , , , , , , , , , , , , , , , , … ( ).

Nov 8, 2023 | biologicalpsychiatryjournal.com | Tyrone D. Cannon

Get full text accessLog in, subscribe or purchase for full access. References1. Salazar de Pablo, G. ∙ Radua, J. ∙ Pereira, J. ... Probability of transition to psychosis in individuals at clinical high risk: An updated meta-analysisJAMA Psychiatry. 2021; 78:970-9782. Worthington, M.A. ∙ Cannon, T.D.Prediction and prevention in the clinical high-risk for psychosis paradigm: A review of the current status and recommendations for future directions of inquiryFront Psychiatry. 2021; 12, 7707743.

Nov 1, 2023 | ajp.psychiatryonline.org | Tyrone D. Cannon

In the present issue of the American Journal of Psychiatry, Smucny et al. suggest that predictive algorithms for psychosis using machine learning (ML) methods may already achieve a clinically useful level of accuracy (1). In support of this perspective, these authors report on the results of an analysis using the North American Prodrome Longitudinal Study, Phase 3 (NAPLS3) data set (2), which they accessed through the National Institute of Mental Health Data Archive (NDAR).