Cecile Tissot

Sep 25, 2023 | nature.com | Bruna Bellaver |Guilherme Povala |Joseph Therriault |Cecile Tissot |Carolina Soares |Yi-ting Wang | +6 more

AbstractThe mechanisms by which the apolipoprotein E ε4 (APOEε4) allele influences the pathophysiological progression of Alzheimer’s disease (AD) are poorly understood. Here we tested the association of APOEε4 carriership and amyloid-β (Aβ) burden with longitudinal tau pathology.

Aug 31, 2023 | nature.com | Wagner S. Brum |Eduardo Zimmer |Joseph Therriault |Cecile Tissot |Hartmuth C. Kolb |Sebastian Palmqvist | +2 more

AbstractCost-effective strategies for identifying amyloid-β (Aβ) positivity in patients with cognitive impairment are urgently needed with recent approvals of anti-Aβ immunotherapies for Alzheimer’s disease (AD). Blood biomarkers can accurately detect AD pathology, but it is unclear whether their incorporation into a full diagnostic workflow can reduce the number of confirmatory cerebrospinal fluid (CSF) or positron emission tomography (PET) tests needed while accurately classifying patients.

Aug 3, 2023 | alz-journals.onlinelibrary.wiley.com | Joseph Therriault |Cecile Tissot |João Pedro Ferrari-Souza |Andrea L. Benedet

Abstract INTRODUCTION Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify Aβ and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI). METHODS We assessed 138 CU and 87 CI with available plasma p-tau231, 217+, and 181, Aβ42/40, GFAP and Aβ- and tau-PET.

Apr 27, 2023 | nature.com | Laia Montoliu-Gaya |Cecile Tissot |Agathe Vrillon |Wagner S. Brum |Juan Lantero-Rodriguez |Johanna Nilsson | +5 more

AbstractBlood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimerʼs disease (AD). However, knowledge on the optimal marker for disease identification across the AD continuum and the link to pathology is limited. This is partly due to heterogeneity in analytical methods.