Hartmuth C. Kolb

Sep 25, 2023 | nature.com | Bruna Bellaver |Guilherme Povala |Joseph Therriault |Cecile Tissot |Carolina Soares |Yi-ting Wang | +6 more

AbstractThe mechanisms by which the apolipoprotein E ε4 (APOEε4) allele influences the pathophysiological progression of Alzheimer’s disease (AD) are poorly understood. Here we tested the association of APOEε4 carriership and amyloid-β (Aβ) burden with longitudinal tau pathology.

Aug 31, 2023 | nature.com | Wagner S. Brum |Eduardo Zimmer |Joseph Therriault |Cecile Tissot |Hartmuth C. Kolb |Sebastian Palmqvist | +2 more

AbstractCost-effective strategies for identifying amyloid-β (Aβ) positivity in patients with cognitive impairment are urgently needed with recent approvals of anti-Aβ immunotherapies for Alzheimer’s disease (AD). Blood biomarkers can accurately detect AD pathology, but it is unclear whether their incorporation into a full diagnostic workflow can reduce the number of confirmatory cerebrospinal fluid (CSF) or positron emission tomography (PET) tests needed while accurately classifying patients.