Chaodong Ge

Oct 1, 2024 | cell.com | Zhejiang Province |Liang Tao |Xinquan Yang |Chaodong Ge |Peng Zhang |Xingbo Xu | +9 more

KeywordsMASHiron chelatoriron metabolismferroptosisFerroTerminator1FOT1ACSL4c-MYCserum ferritinliver diseaseIntroductionThe prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD),11. Lazarus, J.V. ∙ Mark, H.E. ∙ Allen, A.M. ... A global research priority agenda to advance public health responses to fatty liver diseaseJ. Hepatol.

Aug 13, 2024 | cell.com | Liang Tao |Xinquan Yang |Chaodong Ge |Peng Zhang

Highlights • The prevalence and progression of MAFLD are associated with excess hepatic iron levels • Iron aggravates the development of MASH primarily via c-MYC-ACSL4-induced ferroptosis • FOT1 alleviates MASH by simultaneously blocking iron accumulation and ferroptosis • Serum ferritin may be a predictive biomarker for iron chelator-targeted MASH therapy Summary The complex etiological factors associated with metabolic dysfunction-associated fatty liver disease (MAFLD), including perturbed...