Liang Tao

Oct 2, 2024 | nature.com | Xinchen Lv |Yuanyuan Zhang |Jianhua Luo |Liang Tao

AbstractClostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge. Here we present the de novo design and characterization of pan-specific mini-protein binders against major TcdB subtypes.

Oct 1, 2024 | cell.com | Zhejiang Province |Liang Tao |Xinquan Yang |Chaodong Ge |Peng Zhang |Xingbo Xu | +9 more

KeywordsMASHiron chelatoriron metabolismferroptosisFerroTerminator1FOT1ACSL4c-MYCserum ferritinliver diseaseIntroductionThe prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD),11. Lazarus, J.V. ∙ Mark, H.E. ∙ Allen, A.M. ... A global research priority agenda to advance public health responses to fatty liver diseaseJ. Hepatol.

Aug 13, 2024 | cell.com | Liang Tao |Xinquan Yang |Chaodong Ge |Peng Zhang

Highlights • The prevalence and progression of MAFLD are associated with excess hepatic iron levels • Iron aggravates the development of MASH primarily via c-MYC-ACSL4-induced ferroptosis • FOT1 alleviates MASH by simultaneously blocking iron accumulation and ferroptosis • Serum ferritin may be a predictive biomarker for iron chelator-targeted MASH therapy Summary The complex etiological factors associated with metabolic dysfunction-associated fatty liver disease (MAFLD), including perturbed...

Mar 28, 2024 | mdpi.com | Yu Tang |Liang Tao |Yuanqiang Li |Dashan Zhang

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Feb 29, 2024 | mdpi.com | Chunlei Tan |Yang Tian |Liang Tao |Jing Xie

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.