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Jan 10, 2025 | 
journals.plos.org | Steffen Lindner |Charité Universitätsmedizin Berlin |Markus Ralser
The remarkable conservation of metabolic networks across all living systems suggests that the fundamental structure of metabolism was established during the earliest stages of life on Earth, which emerged at least 4 billion years ago. In modern organisms, the metabolic network spans over hundreds of enzymes turning over thousands of different metabolites [1].
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Nov 27, 2024 | 
link.springer.com | Charité Universitätsmedizin Berlin
AbstractScar endometriosis (EM) is defined by the presence of endometrial-like tissue outside the uterine cavity within the scar region after abdominal or pelvic surgery. It is a form of abdominal wall EM. This systematic review addresses the question of whether women after cesarean delivery (CD) are more frequently affected by scar EM than women after other pelvic surgical procedures. The primary aim is to analyze the distribution of previous operations in patients with scar EM.
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Nov 25, 2024 | 
journals.plos.org | Noa L. Hedrich |Universität Hamburg |Charité Universitätsmedizin Berlin |Eric Schulz
Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Hedrich NL, Schulz E, Hall-McMaster S, Schuck NW (2024) An inductive bias for slowly changing features in human reinforcement learning. PLoS Comput Biol 20(11): e1012568. https://doi.org/10.1371/journal.pcbi.1012568Editor: Stefano Palminteri, Ecole Normale Superieure, FRANCEReceived: January 21, 2024; Accepted: October 17, 2024; Published: November 25, 2024Copyright: © 2024 Hedrich et al.
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Nov 13, 2024 | 01320-2&sz=64)
cell.com | Charité Universitätsmedizin Berlin |Humboldt-Universität zu Berlin |Activated Protein C |Daniel Humme
KeywordshistonesMRSAStaphylococcus aureusantimicrobial peptideswall teichoic acidsneutrophil extracellular trapsantimicrobial resistanceResearch topic(s)CP: MicrobiologyIntroductionHistones are a family of proteins that are crucial in packaging DNA in the nucleus of eukaryotic cells.
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Oct 28, 2024 | 
biorxiv.org | Niels A Kloosterman |Anke Braun |Tobias H. Donner |Charité Universitätsmedizin Berlin
AbstractTheoretical accounts postulate that the catecholaminergic neuromodulator noradrenaline shapes cognitive behavior by reducing the impact of prior expectations on learning, inference, and decision-making. A ubiquitous effect of dynamic priors on perceptual decisions under uncertainty is choice history bias: the tendency to systematically repeat, or alternate, previous choices, even when stimulus categories are presented in a random sequence.
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Oct 28, 2024 | 
academic.oup.com | Charité Universitätsmedizin Berlin |Universitaetsmedizin Greifswald
Critically ill patients often suffer from heart and skeletal muscle atrophy and failure (intensive care unit acquired weakness; ICUAW). Inflammation and sepsis are major risk factors for ICUAW. Critically ill patients with sepsis frequently develop insulin resistance that decreases protein synthesis and increases protein degradation in muscle eventually leading to ICUAW.
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Oct 13, 2024 | .html&sz=64)
fis.uke.de | Harald Prüss |Charité Universitätsmedizin Berlin |Sarah Laurent |Agni M Konitsioti
IMPORTANCE: B-cell-targeting monoclonal antibodies have demonstrated safety and efficacy in multiple sclerosis or anti-aquaporin-4 IgG positive neuromyelitis optica spectrum disorder. However, these therapies do not facilitate drug-free remission, which may become possible with cell-based therapies, including chimeric antigen receptor (CAR) T cells. CAR T-cell therapy holds promise for addressing other antibody-mediated CNS disorders, e.g., MOG-associated disease or autoimmune encephalitis.
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Oct 2, 2024 | 
medrxiv.org | Asma Hallab |Charité Universitätsmedizin Berlin
The authors have declared no competing interest. This study was funded by the National Institute on Aging (National Institutes of Health Grant U19 AG024904). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Sep 29, 2024 | 
academic.oup.com | Charité Universitätsmedizin Berlin |Klinik für Endokrinologie
Patients with primary aldosteronism (PA) have higher cardiac comorbidities including more pronounced left ventricular hypertrophy than patients with essential hypertension. Autonomous cortisol co-secretion (ACS) is a common subtype in PA associated with a worse metabolic profile. ACS may affect myocardial parameters and result in a worse cardiac outcome compared to patients with PA and without ACS.
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Sep 27, 2024 | 
onlinelibrary.wiley.com | Charité Universitätsmedizin Berlin |Gabriela Barrientos |Melanie L. Conrad
AD Atopic dermatitis Ahr Aryl hydrocarbon receptor APC Antigen presenting cells Areg Amphiregulin CagA cytotoxin-associated gene A CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CTLA-4 Cytotoxic T lymphocyte antigen 4 DC Dendritic cell DEREG DEpletion of REGulatory T cells FA Food allergy FOXP3 Forkhead box P3 GATA3 GATA-binding protein 3 GGT γ-glutamyl transferase (GGT) HDM House dust mite IgE Immunoglobulin E IL Interleukin ILC Innate lymphoid cell IPEX...
