Universitaetsmedizin Greifswald

Oct 28, 2024 | academic.oup.com | Charité Universitätsmedizin Berlin |Universitaetsmedizin Greifswald

Critically ill patients often suffer from heart and skeletal muscle atrophy and failure (intensive care unit acquired weakness; ICUAW). Inflammation and sepsis are major risk factors for ICUAW. Critically ill patients with sepsis frequently develop insulin resistance that decreases protein synthesis and increases protein degradation in muscle eventually leading to ICUAW.