Charles Leonard

Oct 21, 2024 | ascpt.onlinelibrary.wiley.com | Cheng Chen |Todd Miano |Colleen M. Brensinger |Charles Leonard

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Methadone has a high potential for risky drug–drug interactions (DDIs) that can lead to opioid overdose, yet evidence on the magnitude of this risk remains limited. Theoretically, the potential pharmacokinetic interaction between methadone, a substrate of P-glycoprotein (P-gp), and statins that inhibit P-gp can increase the risk of opioid overdose. WHAT QUESTION DID THIS STUDY ADDRESS?

Aug 16, 2024 | ldi.upenn.edu | Charles Leonard

The following excerpt is from an op-ed that first appeared in PennLive on August 14th, 2024. We’re all sweaty. Last year was the hottest on record, and more heat waves are coming. This will hurt the most vulnerable among us first. People with chronic conditions like diabetes, high blood pressure, depression are already more sensitive to heat. On top of that, their prescription drugs can impair sweating, making them even more susceptible to hot weather.