Todd Miano

Oct 21, 2024 | ascpt.onlinelibrary.wiley.com | Cheng Chen |Todd Miano |Colleen M. Brensinger |Charles Leonard

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Methadone has a high potential for risky drug–drug interactions (DDIs) that can lead to opioid overdose, yet evidence on the magnitude of this risk remains limited. Theoretically, the potential pharmacokinetic interaction between methadone, a substrate of P-glycoprotein (P-gp), and statins that inhibit P-gp can increase the risk of opioid overdose. WHAT QUESTION DID THIS STUDY ADDRESS?

Mar 14, 2024 | ascpt.onlinelibrary.wiley.com | Cheng Chen |Sean Hennessy |Colleen M. Brensinger |Todd Miano

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Concurrent use of opioids and skeletal muscle relaxants (SMRs) may cause oversedation, predisposing patients to traumatic injury. WHAT QUESTION DID THIS STUDY ADDRESS? We compared the injury rates associated with different SMRs when used concurrently with the three most dispensed opioids—hydrocodone, oxycodone, and tramadol.