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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
MKSAP Answer and Critique
The correct answer is A. Gestational thrombocytopenia. This content is available to
ACP MKSAP subscribers in the Hematology section. More information about ACP MKSAP is available online.
The most likely diagnosis is gestational thrombocytopenia (Option A). Gestational thrombocytopenia is the most common cause of thrombocytopenia in pregnancy,
affecting approximately 5% of pregnant persons. The cause is uncertain.
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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
https://immattersacp.org/weekly/archives/2025/05/20/1.htm
I.M. Matters Weekly | Diet | May 20, 2025
While calorie-restrictive and low-fat diets may reduce symptoms of depression in those
with high cardiometabolic risk, the certainty of the findings is low, according to
a new systematic review and meta-analysis. There was insufficient evidence to assess
the Mediterranean diet's effects.
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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
I.M. Matters Weekly from ACP has tallied the voting from its latest cartoon contest, where readers are invited
to match wits against their peers to provide the most original and amusing caption.
“I asked for an office with a view.”
This issue's winning cartoon caption was submitted by Mark R. Stringer, an ACP Medical
Student Member. Thanks to all who voted! The winning entry captured 35% of the votes.
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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
Amiloride, a potassium-sparing diuretic, may be an alternative to spironolactone as
a fourth-line drug in patients with resistant hypertension, according to a recent
study.
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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
Treatment episodes for HIV pre-exposure prophylaxis (PrEP) are shortening, despite
increased dispensing and starting of PrEP among young adults, a study found.
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2 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
ACP and Annals of Internal Medicine presented “Alcohol: Is Any Amount Safe for Health?” on Wednesday, May
14. The virtual forum for ACP members and Annals subscribers featured expert panelists discussing alcohol, including clinical case
scenarios involving alcohol consumption, with evidence from recently published research
and guidelines. Rebecca A.
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3 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
https://immattersacp.org/weekly/archives/2025/05/13/1.htm
I.M. Matters Weekly | Colorectal cancer screening | May 13, 2025
Fecal immunochemical tests (FITs) would still be more cost-effective than multitarget
and next-generation stool DNA tests even if the other tests' costs were lowered to
$100, a recent analysis found.
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3 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
https://immattersacp.org/weekly/archives/2025/05/13/2.htm
I.M. Matters Weekly | Vaccination | May 13, 2025
An mRNA vaccine candidate that combines flu and COVID-19 vaccinations elicited noninferior
immune responses versus the standard flu and COVID-19 vaccines in a trial of patients
ages 50 years and older, a study by Moderna found.
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3 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
MKSAP Answer and Critique
The correct answer is A. Botulism. This content is available to ACP MKSAP subscribers
in the Infectious Disease section. More information about ACP MKSAP is available online.
The most likely diagnosis is botulism (Option A). Botulism can be acquired by ingestion, inhalation, or wound contamination.
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3 weeks ago | 
immattersacp.org | Charlotte Huff |Gianna Melillo |ACP Internist
A person who has a nonoccupational exposure to nonintact skin or mucous membranes
that presents substantial risk for HIV transmission should receive nonoccupational
postexposure prophylaxis (nPEP) if the source has HIV without known sustained viral
suppression, according to new recommendations from the CDC.
nPEP is not recommended if the exposure presents no substantial risk for HIV transmission
and should be stopped if at any point the source is found to not have HIV, the CDC
said.
