Charneal Dixon

Jan 11, 2025 | biorxiv.org | Charneal Dixon |Noah Martin |Micah J. Niphakis |Benjamin Cravatt

AbstractBACKGROUND AND AIMS: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for microbial surveillance. This membrane targeting is achieved through post-translational S-acylation of NOD2 by the protein acyltransferase ZDHHC5. Membrane attachment is necessary to initiate a signaling cascade in response to cytosolic peptidoglycan fragments.

Dec 21, 2023 | biorxiv.org | Noah Martin |Micah J. Niphakis |Benjamin Cravatt |Charneal Dixon

AbstractNOD2 is an intracellular innate immune receptor that senses bacterial peptidoglycans. Although soluble in the cytosol, some protein is associated with the plasma membrane and endosomal compartments for microbial surveillance. Palmitoylation of NOD2 by zDHHC5 promotes its membrane recruitment to drive proinflammatory and antimicrobial responses to pathogenic invasion.