Charu Ramakrishnan

Sep 13, 2023 | nature.com | Sebastien Tremblay |Sébastien Tremblay |Ilyas Singeç |Clifford J. Woolf |Matthew Hayes |F. Christian Bennett | +4 more

AbstractWith concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools and transgenic models for gaining long-term genetic access to MOR+ neural cell types and circuits involved in modulating pain, analgesia and addiction across species are limited.

Aug 17, 2023 | nature.com | Charu Ramakrishnan |Robert C. Malenka

AbstractAnimals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear.