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1 month ago | 
dx.doi.org | Zhijie Chen |Christopher Jensen |Chen Liu |Yijing Liu
The emergence of generative artificial intelligence, which are machine learning models that create new content by learning and emulating patterns from existing data sets, has led to significant advancements and widespread application of large language models like ChatGPT.
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Feb 19, 2025 | 
biorxiv.org | Chen Liu |Young-Jun Park |Cheng-Bao Ma |Cameron Stuart
AbstractDipeptidyl peptidase-4 (DPP4) is a well-established receptor for several MERS-related coronaviruses (MERSr-CoVs) isolated from humans, camels, pangolins, and bats. However, the receptor usage of many genetically diverse bat MERSr-CoVs with broad geographical distributions remains poorly understood. Recent studies have identified angiotensin-converting enzyme 2 (ACE2) as an entry receptor for multiple merbecovirus clades.
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Dec 2, 2024 | 
mdpi.com | Desheng Xu |Chen Liu |Qing Du |Wei Duan
1. IntroductionDriven by China’s coal-rich, oil-poor, and gas-poor fossil resource endowment and the continuous strong consumption of downstream petrochemical products, the modern coal chemical industry has developed rapidly into an important supplement to the petrochemical industry [1,2]. In recent years, although the production scale of the coal chemical industry has been continuously expanding, overall, the production of olefins from petroleum is still in the main position.
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Oct 25, 2024 | 
onlinelibrary.wiley.com | Lin Li |Ziling Jiang |Jie Yang |Chen Liu
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202410008-sup-0001-SuppMat.docx4.4 MB Supporting Information References 1, , Nat. Chem. 2015, 7, 19. 2, , , , , , , , , , Small 2024, 20, 2401502. 3, , , , Nat. Energy 2017, 3, 16. 4, , , , , , , , , Chin. Chem. Lett. 2024, 35, 108717. 5, , , , , , , , , , , Ind. Eng. Chem. Res. 2024, 63, 7699. 6, , , , , , , , Adv. Funct. Mater. 2022, 32, 2203095.
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Sep 18, 2024 | 
pubs.rsc.org | Juergen Popp |Edoardo Farnesi |Matteo Calvarese |Chen Liu
Advancing cerumen analysis: exploring innovative vibrational spectroscopy techniques with respect their potential as new point-of-care diagnostic tool
Cerumen, commonly known as earwax, is a complex mixture composed of secretions from ceruminous glands. These secretions are known as heterogeneous mixture mainly composed of lipids and proteins. Despite its prevalence, the potential diagnostic value of cerumen remains largely unexplored.
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Sep 5, 2024 | 
nature.com | Fang-Fei Wei |Pierpaolo Pellicori |Joao Ferreira |Arantxa González |De-Wei An |Chen Liu | +10 more
AbstractNone of the spironolactone trials in heart failure (HF) assessed the blood pressure (BP) responses to exercise, while conflicting results were reported for exercise capacity. In the HOMAGE trial, 527 patients at increased HF risk were randomized to usual treatment with or without spironolactone (25–50 mg/day). The current substudy included 113 controls and 114 patients assigned spironolactone, who all completed the incremental shuttle walk test at baseline and months 1 and 9.
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Aug 28, 2024 | 
biorxiv.org | Young-Jun Park |Chen Liu |Jimin Lee |Jack Brown
AbstractDPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity with which merbecoviruses engage ACE2 and their receptor species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pipistrellus abramus (P.abr) and several non-bat mammalian ACE2s through a binding mode distinct from that of any other known ACE2-using coronaviruses.
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May 1, 2024 | 
mdpi.com | Siyi Han |Chen Liu |Yaping Zhou
Among the works written by Catholic missionaries in the late Ming and early Qing dynasties, the most widely influential are Matteo Ricci’s (利瑪竇) The True Meaning of the Lord of Heaven (天主實義), Twenty-Five Sayings (二十五言), and On Friendship (交友論), and Diego de Pantoja’s (龐迪我) The Seven Victories (七克), which were all included in the Siku Quanshu Congmu (四庫全書存目).
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Mar 11, 2024 | 
pubs.rsc.org | Dengyue Chen |Chen Liu |Jiaqi Guo |Jieli Yin
A Copper-loaded Self-assembled Nanoparticle for Disturbing the Tumor Redox Balance and Triple Anti-tumor Therapy
Both chemodynamic therapy and photodynamic therapy, based on the production of reactive oxygen (ROS), have excellent potential in cancer therapy. However, the abnormal redox homeostasis in tumor cells, especially the overexpressed glutathione (GSH) could scavenge ROS and reduce the anti-tumor efficiency.
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Feb 6, 2024 | 
mdpi.com | Yubo Wang |Lu Zhang |Chen Liu |Yiming Luo
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