Cheng-Bao Ma

Feb 19, 2025 | biorxiv.org | Chen Liu |Young-Jun Park |Cheng-Bao Ma |Cameron Stuart

AbstractDipeptidyl peptidase-4 (DPP4) is a well-established receptor for several MERS-related coronaviruses (MERSr-CoVs) isolated from humans, camels, pangolins, and bats. However, the receptor usage of many genetically diverse bat MERSr-CoVs with broad geographical distributions remains poorly understood. Recent studies have identified angiotensin-converting enzyme 2 (ACE2) as an entry receptor for multiple merbecovirus clades.