Chen-Yang Su

Jul 22, 2024 | biorxiv.org | Wenmin Zhang |Chen-Yang Su |Satoshi Yoshiji |Tianyuan Lu

AbstractSummaryMendelian randomization is being utilized to assess causal effects of polygenic exposures, where many genetic instruments are subject to horizontal pleiotropy. Existing methods for detecting and correcting for horizontal pleiotropy have important assumptions that may not be fulfilled. Built upon the core gene hypothesis, we developed MR Corge for performing sensitivity analysis of Mendelian randomization.