Chen-Yang Su

Jul 22, 2024 | biorxiv.org | Wenmin Zhang |Chen-Yang Su |Satoshi Yoshiji |Tianyuan Lu

AbstractSummaryMendelian randomization is being utilized to assess causal effects of polygenic exposures, where many genetic instruments are subject to horizontal pleiotropy. Existing methods for detecting and correcting for horizontal pleiotropy have important assumptions that may not be fulfilled. Built upon the core gene hypothesis, we developed MR Corge for performing sensitivity analysis of Mendelian randomization.

Feb 20, 2023 | nature.com | Satoshi Yoshiji |Guillaume Butler-Laporte |Tianyuan Lu |Chen-Yang Su |Tomoko Nakanishi |David Morrison | +5 more

AbstractObesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization.