Tianyuan Lu

Jul 22, 2024 | biorxiv.org | Wenmin Zhang |Chen-Yang Su |Satoshi Yoshiji |Tianyuan Lu

AbstractSummaryMendelian randomization is being utilized to assess causal effects of polygenic exposures, where many genetic instruments are subject to horizontal pleiotropy. Existing methods for detecting and correcting for horizontal pleiotropy have important assumptions that may not be fulfilled. Built upon the core gene hypothesis, we developed MR Corge for performing sensitivity analysis of Mendelian randomization.

Nov 2, 2023 | nature.com | Maria Nethander |Sofia Movérare-Skrtic |Anders Kämpe |Ene Reimann |Louise Grahnemo |Martine Cohen-Solal | +10 more

AbstractOsteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci.

May 22, 2023 | mdpi.com | Tianyuan Lu |Lei Wang |Xiaoyong Zhao

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReviewbyTianyuan Lu, Lei Wang * and Xiaoyong Zhao School of Information Management, Beijing Information Science and Technology University, Beijing 100192, China*Author to whom correspondence should be addressed. Appl. Sci.

Feb 20, 2023 | nature.com | Satoshi Yoshiji |Guillaume Butler-Laporte |Tianyuan Lu |Chen-Yang Su |Tomoko Nakanishi |David Morrison | +5 more

AbstractObesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization.