Cheng Shang

2 months ago | onlinelibrary.wiley.com | Alasdair Keith |Elizabeth Sawyer |James Cole |Cheng Shang

1 INTRODUCTION Catabolism of exogenous haem by bacterial pathogens is typically mediated by a haem oxygenase (HO) via a process requiring three O2 molecules, and ultimately yielding regiospecific biliverdin and CO alongside the extracted Fe2+ ion (Lyles and Eichenbaum 2018; Maines and Kappas 1974; Unno et al. 2007; Wilks and Heinzl 2014; Wilks and Ikeda-Saito 2014). Many bacterial pathogens are facultatively anaerobic and can thus thrive under oxygen-depleted conditions (André et al.