Elizabeth Sawyer

Jan 28, 2025 | onlinelibrary.wiley.com | Alasdair Keith |Elizabeth Sawyer |James Cole |Cheng Shang

1 INTRODUCTION Catabolism of exogenous haem by bacterial pathogens is typically mediated by a haem oxygenase (HO) via a process requiring three O2 molecules, and ultimately yielding regiospecific biliverdin and CO alongside the extracted Fe2+ ion (Lyles and Eichenbaum 2018; Maines and Kappas 1974; Unno et al. 2007; Wilks and Heinzl 2014; Wilks and Ikeda-Saito 2014). Many bacterial pathogens are facultatively anaerobic and can thus thrive under oxygen-depleted conditions (André et al.

Aug 14, 2023 | pubs.rsc.org | Alasdair Keith |Elizabeth Sawyer |Yuhang Xie |George Biggs

Combining Experiment and Energy Landscapes to Explore Anaerobic Heme Breakdown in Multifunctional Hemoproteins To survive, many pathogens extract heme from their host organism and break down the porphyrin scaffold to sequester the Fe2+ ion via a heme oxygenase. Recent studies have revealed that certain pathogens can anaerobically degrade heme.