Cheng Zhao

Nov 21, 2024 | lupus.bmj.com | Ying Zhang |Cheng Zhao |Yu Lei |Qilin Li

Systemic lupus erythematosus (SLE) severely impacts patients’ health and quality of life. While genetic factors play a crucial role in its onset, exposure to environmental and occupational risk factors also significantly increases the risk of developing SLE. Existing predictive models often fail to adequately consider the influence of these factors on SLE development.

Nov 15, 2023 | onlinelibrary.wiley.com | Yin Zhang |Ranran Yu |Cheng Zhao |Jiawei Liang

1 Introduction Pancreatic cancer is a devastating malignancy characterized by a high fatality rate,[1] primarily attributed to the formidable challenges in early diagnosis.[2] BRD4, a member of the Bromodomain and Extraterminal (BET) protein family, is a promising target for anticancer drugs due to its involvement in organizing super-enhancers (SEs) and regulating the expression of oncogenes.[3] Inhibiting BRD4 disrupts the communication between SEs and target promoters, leading to the...

Sep 15, 2023 | journals.plos.org | Yue Zhai |Macau SAR |Xin Zhang |Cheng Zhao

Fig 8. Role of inhbaa in the partial rescue of vitellogenic growth in bmp15-/- by inha-/-. (A) Morphology and histology of the gonads in different genotypes at 120 dpf. The asterisk shows vitellogenic follicles without yolk mass in the triple mutant (bmp15-/-;inha-/-;inhbaa-/-). (B) Oocytes from diffident genotypes at higher magnification. The oocytes in bmp15-/- single mutant were arrested at PV stage with cortical alveoli (CA) but no yolk granules (YG).