Ranran Yu

Jun 27, 2024 | biorxiv.org | Tao Zhu |Chunjiao Xia |Ranran Yu |Xinkai Zhou

AbstractUnraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three representative varieties. Our study uncovers 117,176 unique open chromatin regions (OCRs), accounting for ~15% of the rice genome, a notably higher proportion compared to previous reports in plants.

Nov 15, 2023 | onlinelibrary.wiley.com | Yin Zhang |Ranran Yu |Cheng Zhao |Jiawei Liang

1 Introduction Pancreatic cancer is a devastating malignancy characterized by a high fatality rate,[1] primarily attributed to the formidable challenges in early diagnosis.[2] BRD4, a member of the Bromodomain and Extraterminal (BET) protein family, is a promising target for anticancer drugs due to its involvement in organizing super-enhancers (SEs) and regulating the expression of oncogenes.[3] Inhibiting BRD4 disrupts the communication between SEs and target promoters, leading to the...