Chenyao Li

Jul 22, 2024 | link.aps.org | Lei Jin |Chenyao Li |Ying Liu |Zining Hu

The charge-2 (C2) triple point (TP) is a zero-dimensional threefold band degeneracy with a topological charge |C|=2. Different from other types of TP, the C2 TP is expected to have novel physical properties because of its nonzero topological charge. However, the C2 TP is only found in nonmagnetic materials and has not been found in realistic magnetic materials. In this work, we systematically study such fermions in nonmagnetic and ferromagnetic systems.

Apr 29, 2024 | nature.com | Yaqi Zhou |Sijie Liu |Chenyao Li |Xiangrui Kong |Lei Zhang |Xinying Ji | +3 more

Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting protein kinase (RIPK) family with serine/threonine protein kinase activity, interacts with RIPK1 to generate necrosomes, which trigger caspase-independent programmed necrosis. As a vital component of necrosomes, RIPK3 plays an indispensable role in necroptosis, which is crucial for human life and health. In addition, RIPK3 participates in the pathological process of several infections, aseptic inflammatory diseases, and tumors (including tumor-promoting and -suppressive activities) by regulating autophagy, cell proliferation, and the metabolism and production of chemokines/cytokines. This review summarizes the recent research progress of the regulators of the RIPK3 signaling pathway and discusses the potential role of RIPK3/necroptosis in the aetiopathogenesis of various diseases. An in-depth understanding of the mechanisms and functions of RIPK3 may facilitate the development of novel therapeutic strategies.