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2 months ago | 
mdpi.com | Chunheng Liu |Fang Zhang |Lei Zhang |Jun Peng
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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2 months ago | 
onlinelibrary.wiley.com | Zhimin Gao |Lei Zhang |Zhen Li |Xu Qin
1 Introduction There is an increasing variety of treatment options regarding locally advanced or metastatic urothelial carcinoma (UC), such as immune checkpoint inhibitors (ICIs) [1], antibody–drug conjugates (ADCs) [2], and fibroblast growth factor receptor (FGFR) inhibitors [3]. Nevertheless, the standard initial therapeutic approach for advanced bladder cancer (BC) still involves combination chemotherapy based on cisplatin [4].
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Feb 5, 2025 | 
science.org | Brynna G. Downey |Lu Shen |Xin Yao |Ying Qu |Ashok Mishra |Michael E. Mann | +13 more
AbstractThe elderly face elevated mortality risk due to rising temperature. Previous assessments of temperature-related mortality, however, lack a comprehensive analysis of distinct impacts of temperature change across different timescales and characteristics.
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Jan 28, 2025 | 
mdpi.com | Meixuan Li |Zhiguo Huo |Qianchuan Mi |Lei Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jan 19, 2025 | 
nature.com | Lei Zhang |Bo Chu
AbstractS-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on cysteine 66. The acyltransferase ZDHHC20 palmitoylates GPX4 and increases its protein stability. ZDHHC20 depletion or inhibition of protein palmitoylation by 2-BP sensitizes cancer cells to ferroptosis.
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Jan 16, 2025 | 
sciencedirect.com | Zhihao Xu |Zhifeng Yang |Chunxia Xu |Lei Zhang
As a type of inland water system, reservoirs play an important role in regulating water resources, changing hydrological characteristics (Feng et al., 2023), regulating the carbon cycle, and influencing greenhouse gases (Tranvik et al., 2009). Located in Fujian Provincein southeast China, Shanmei reservoir has a total storage capacity of 655 million cubic meters, making it the largest reservoirunder the jurisdiction of the Fujian Provincial Water Resources Department.
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Jan 16, 2025 | 
mdpi.com | Lei Zhang |Yile Chen |Liang Zheng |Ruyi Zheng
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jan 16, 2025 | 
mdpi.com | Xueli Yang |Bolin Liu |Lei Zhang |Xiaodan Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jan 15, 2025 | 
mdpi.com | Jinlong Zhang |Jianing Zhang |Lei Zhang |Weimin Chen
1. IntroductionWith global climate change, the extent, thickness, and concentration of ice have generally decreased. In polar environments, level ice breaks down into floating brash ice, which takes on various shapes under the combined action of wind, waves, and currents. There are increasingly more brash ice areas in polar regions. Therefore, studying the load characteristics of ships in brash ice channels is crucial for guiding ship design in polar ice regions.
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Jan 15, 2025 | 
mdpi.com | Jiasheng Ling |Lei Zhang |Chenyang Liu |Guoxin Xia
1. IntroductionIndustrial control systems (ICSs), as the core of critical infrastructure, are widely used in power, water supply, and manufacturing industries. However, with the continuous development of network technology, the cyber-security of ICSs faces serious challenges. Cyber-attacks not only lead to information leakage but may also cause damage to physical equipment, casualties, and environmental damage. Therefore, it is crucial to ensure the security of ICSs [1].
