Chi Ho Lee

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Articles

Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese

Nov 1, 2023 | cell.com | Bariatric Surgery |Guangdong Pharmaceutical |Jacob George |Chi Ho Lee

Highlights•Circulating sCDCP1 is the top-ranked classifier of NASH by Olink proteomics analysis•Hepatic mRNA abundance of CDCP1 is significantly elevated in patients with NASH•The decrease in sCDCP1 mirrors changes in liver enzymes after bariatric surgery•An sCDCP1-based algorithm shows excellent performance for risk stratification of NASHSummaryThe definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy.

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