Chris Anderson

Contributor at Inside Precision Medicine

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Articles

Liquid Biopsy Uses mRNA to Diagnose Cancer, Treatment Resistance, Tissue Damage

1 day ago | insideprecisionmedicine.com | Chris Anderson

Stanford Medicine researchers have developed a new liquid biopsy that detects cancer, resistance to cancer therapies, and tissue damage from noncancerous conditions by analyzing messenger RNA (mRNA) circulating in the bloodstream. The research, published in Nature, details this new method called RARE-seq (random priming and affinity capture of cfRNA fragments for enrichment analysis by sequencing), which took more than six years of work to make circulating RNA a viable clinical biomarker.
Psychedelic Compound’s Weeks-Long Effects Show Promise for Mental Health, Neurologic Treatments

2 days ago | insideprecisionmedicine.com | Chris Anderson

Researchers from the University of Michigan (UM) have found that a single dose of the psychedelic compound 25CN-NBOH significantly enhanced cognitive flexibility in mice for up to three weeks after administration.
GLP-1 Drug Show Potential as Treatment for Bardet-Biedl Syndrome

3 days ago | insideprecisionmedicine.com | Chris Anderson

Treatment with GLP-1 receptor agonists—medications currently approved for type 2 diabetes and obesity—may offer a new therapeutic option for patients with the rare genetic disorder Bardet-Biedl Syndrome (BBS). The study, published in the Journal of Clinical Investigation, which used engineered mouse model that mirror many features of human BBS, found that GLP-1 therapies significantly improved metabolic function, reduced food intake, and helped normalize hormone levels.
Decreased Activity of Key Enzyme Accelerates Immune System Aging

6 days ago | insideprecisionmedicine.com | Chris Anderson

Researchers from the University of California, San Diego (UCSD), and UC Irvine have demonstrated that decreased activity of a lipid-synthesizing enzyme called ELOVL2 accelerates immune system aging by disrupting B cell development and altering gene expression linked to cancer. The study, published in GeroScience, found that when ELOVL2 function is impaired, it disrupts the lipid balance within cells and impairs the production of B cells, the white blood cells needed for antibody generation.
Unnecessary Atherosclerosis Surgeries Could Be Avoided with Risk Tool

1 week ago | insideprecisionmedicine.com | Chris Anderson

University College London (UCL) researchers say that they have developed a new risk scoring tool that could help prevent unnecessary surgeries and stents in patients now considered at risk of stroke and heart attack. The tool, called the Carotid Artery Risk (CAR) score, stratifies patients with asymptomatic carotid atherosclerosis based on age, sex, and common cardiovascular risk factors to effectively predict future stroke and heart attack risk.
Combination Therapy Shows 65% Response Rate in Rare Lymphoma

1 week ago | insideprecisionmedicine.com | Chris Anderson

A combination immunotherapy targeting PD-1 and CD38 achieved a 65% objective response rate in patients with relapsed extranodal NK/T-cell lymphoma (ENKTL), according to a multinational Phase II clinical trial by researchers from the National Cancer Centre Singapore (NCCS). The findings, published in Blood, also confirmed that specific genetic markers—including structural variations disrupting the 3′-UTR of the PD-L1 gene—can predict which patients are most likely to benefit from the treatment.
Newly Identified Immune Cells May Offer Path to Treating Food Allergies

1 week ago | insideprecisionmedicine.com | Chris Anderson

A newly identified class of immune cells in the gut may hold the key to treating food allergies, according to a study published in Nature by researchers at NYU Langone Health. The cells, called tolerogenic dendritic cells, normally regulate immune responses caused by exposure to food proteins but can cause food allergies if they malfunction.
Sleep Timing, Quality, and Regularity Affect Cardiovascular Risk

1 week ago | insideprecisionmedicine.com | Chris Anderson

A comprehensive scientific statement released by the American Heart Association (AHA) concludes that healthy sleep is far more than just hours spent asleep each night. It also includes other components such as how long it takes to fall asleep, daytime functioning, and self-reported sleep satisfaction.
New T Cell Priming Discovery Could Boost Immunotherapy Development

1 week ago | insideprecisionmedicine.com | Chris Anderson

A new study from researchers at the Max Planck Research Group at the Julius-Maximilians-University Würzburg, Germany, shows that the immune system activates T cells in a two-phase process, not one as previously thought.
Parkinson’s and Melanoma Linked to DNA Repair Role of Alpha-Synuclein

2 weeks ago | insideprecisionmedicine.com | Chris Anderson

Research from a team of investigators at Oregon Health & Science University (OHSU) has found that alpha-synuclein (αSyn), a protein long associated with neurodegeneration in Parkinson’s disease, also plays a direct role in the development of melanoma by enhancing DNA repair in cancer cells. The research provides a new understanding of αSyn’s dual role and context to long-standing observations that people with Parkinson’s disease are significantly more likely to develop melanoma, and vice versa.