Chris Habrian

Apr 12, 2024 | biorxiv.org | Marina Casiraghi |Haoqing Wang |Patrick Brennan |Chris Habrian

AbstractG protein coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of G protein coupling specificity. The β2-adrenergic receptor is an example of GPCR with high selectivity for Gαs, the stimulatory G protein for adenylyl cyclase, and much weaker for the Gαi family of G proteins inhibiting adenylyl cyclase.

Apr 10, 2024 | biorxiv.org | Marina Casiraghi |Haoqing Wang |Patrick Brennan |Chris Habrian

AbstractG protein coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of G protein coupling specificity. The β2-adrenergic receptor is an example of GPCR with high selectivity for Gαs, the stimulatory G protein for adenylyl cyclase, and much weaker for the Gαi family of G proteins inhibiting adenylyl cyclase.

Mar 29, 2024 | biorxiv.org | Marina Casiraghi |Haoqing Wang |Patrick Brennan |Chris Habrian

AbstractG protein coupled receptors (GPCRs) activated by their native hormone or neurotransmitter exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of different GPCR-G protein complexes, little is known about the mechanism of G protein coupling specificity.