Christina Bergonzo

3 weeks ago | pubs.acs.org | Christina Bergonzo |Alexander Grishaev |Simon A. A |J. Michael

Special IssuePublished as part of Journal of Chemical Information and Modeling special issue “Editing DNA and RNA through Computations”. IntroductionClick to copy section linkSection link copied!As revealed in the 2018 and 2020 Critical Assessment of Structure Prediction trials, (1) artificial intelligence (AI) based protein structure prediction outperformed, by a wide margin, the entirety of competing approaches, prevailing over groups of researchers with decades of experience in the field.

3 weeks ago | dx.doi.org | Christina Bergonzo |Alexander Grishaev |Simon A. A |J. Michael

Special IssuePublished as part of Journal of Chemical Information and Modeling special issue “Editing DNA and RNA through Computations”. IntroductionClick to copy section linkSection link copied!As revealed in the 2018 and 2020 Critical Assessment of Structure Prediction trials, (1) artificial intelligence (AI) based protein structure prediction outperformed, by a wide margin, the entirety of competing approaches, prevailing over groups of researchers with decades of experience in the field.

Jan 13, 2025 | chemistry-europe.onlinelibrary.wiley.com | Christina Bergonzo |Rachel Lyon |Zvi Kelman |Thomas Schmidt

Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Oct 28, 2023 | nist.gov | Christina Bergonzo |J. Todd Hoopes |Zvi Kelman

The crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two important structural variables in Fc constructs are the hinge region connecting the Fc to the antigen binding fragments (Fab) and the glycans present in various glycoforms. These components affect receptor binding interactions that mediate immune activation.