J. Todd Hoopes

Oct 28, 2023 | nist.gov | Christina Bergonzo |J. Todd Hoopes |Zvi Kelman

The crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two important structural variables in Fc constructs are the hinge region connecting the Fc to the antigen binding fragments (Fab) and the glycans present in various glycoforms. These components affect receptor binding interactions that mediate immune activation.

Sep 25, 2023 | mdpi.com | Ryan D. Heselpoth |Frederick P. Schwarz |Daniel Nelson |J. Todd Hoopes

1. IntroductionThe increasing global threat of bacterial resistance to traditional antibiotics highlights the need for alternative antimicrobials [1,2,3,4]. One potential antimicrobial strategy involves the use of bacteriophage (or phage)-encoded endolysins [5,6]. These enzymes are primarily peptidoglycan (i.e., cell wall) hydrolases that cleave critical covalent bonds in the cell wall of phage-infected bacteria.