Christina Dardani

3 weeks ago | nature.com | Christina Dardani |Hannah J. Jones |Evie Stergiakouli |Jakob Grove |Andrew McIntosh |Andrew Mcintosh | +3 more

AbstractImmune dysfunction is implicated in the aetiology of psychiatric, neurodevelopmental, and neurodegenerative conditions, but the issue of causality remains unclear impeding attempts to develop new interventions. Using genomic data on protein and gene expression across blood and brain, we assessed evidence of a potential causal role for 736 immune response-related biomarkers on 7 neuropsychiatric conditions by applying Mendelian randomization (MR) and genetic colocalisation analyses.