Christina J. Flaxel

Dec 3, 2023 | ophthalmologyscience.org | Jeremy Keenan |Catherine Psaras |Christina J. Flaxel

ABSTRACTMetformin use has been associated with a decreased risk of age-related macular degeneration (AMD) progression in observational studies. We aimed to evaluate the efficacy of oral metformin for slowing geographic atrophy (GA) progression. Parallel-group, multicenter, randomized phase 2 clinical trial. Participants aged at least 55 years without diabetes who had GA from atrophic AMD in at least 1 eye.

Aug 13, 2023 | ophthalmologyscience.org | Christina J. Flaxel |Steven Bailey |David Wilson |David Huang

Abstract (348/350)To assess whether the combination of en face OCT and OCT angiography (OCTA) can capture observable, but subtle structural changes that precede clinically evident retinal neovascularization (RNV) in eyes with diabetic retinopathy (DR). Retrospective, longitudinal study. Patients with DR had at least two visits. We obtained wide-field OCTA scans of one eye from each participant and generated en face OCT, en face OCTA, and cross-sectional OCTA.