Christina M. Reumiller

Sep 9, 2023 | nature.com | Sara G. Romeo |Ilaria Secco |Edoardo Schneider |Christina M. Reumiller |Xiaoke Yin |Konstantinos Theofilatos | +6 more

AbstractThe microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulate key features of the human microvasculature, including the reliance of mature endothelial cells on glycolytic metabolism, as concluded from metabolic flux assays and mass spectrometry-based metabolomics using stable tracing of 13C-glucose.