Ilaria Secco

Mar 10, 2024 | nature.com | Mahmoud Ahmed |Nicholas T. Lam |Ivan Menendez-Montes |Ilaria Secco |Mateusz D. Tomczyk |Diana R. Tomchick | +4 more

AbstractTargeting Meis1 and Hoxb13 transcriptional activity could be a viable therapeutic strategy for heart regeneration. In this study, we performd an in silico screening to identify FDA-approved drugs that can inhibit Meis1 and Hoxb13 transcriptional activity based on the resolved crystal structure of Meis1 and Hoxb13 bound to DNA.

Sep 9, 2023 | nature.com | Sara G. Romeo |Ilaria Secco |Edoardo Schneider |Christina M. Reumiller |Xiaoke Yin |Konstantinos Theofilatos | +6 more

AbstractThe microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulate key features of the human microvasculature, including the reliance of mature endothelial cells on glycolytic metabolism, as concluded from metabolic flux assays and mass spectrometry-based metabolomics using stable tracing of 13C-glucose.