Christina R. Dollahon

Dec 1, 2024 | nature.com | Christina R. Dollahon |Vlad C. Sandulache

AbstractNuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance. Whether this model is applicable to normal and cancer nuclei in human tissues is unclear.

Nov 21, 2024 | nature.com | Brendan McKee |Aakansha Shaji |Pushkar Lele |Daniel Conway |Akhilesh K Gaharwar |Christina R. Dollahon

AbstractExtracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization. We investigated the role of the nuclear lamina in this process. We show that the nuclear lamina exhibits mechanical threshold behavior: once unwrinkled, the nuclear lamina is inextensible.