Pushkar Lele

Nov 21, 2024 | nature.com | Brendan McKee |Aakansha Shaji |Pushkar Lele |Daniel Conway |Akhilesh K Gaharwar |Christina R. Dollahon

AbstractExtracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization. We investigated the role of the nuclear lamina in this process. We show that the nuclear lamina exhibits mechanical threshold behavior: once unwrinkled, the nuclear lamina is inextensible.