Christina V. Theodoris

Jan 8, 2025 | nature.com | Christina V. Theodoris

NEWS AND VIEWS 08 January 2025 An artificial-intelligence model trained on data about where DNA is tightly packaged and where it is open to regulators can predict gene expression and interactions between transcription factors that regulate key genes. For cells in a multicellular organism to have diverse roles, each cell must express a different set of proteins that enable it to carry out its functions, enforce its gene-regulatory state and react to stimuli.

Jan 7, 2025 | flipboard.com | Christina V. Theodoris

1 day agoAncient evidence suggests a new twist in how we all got here. In a new peer reviewed analysis, scientists quantify amino acids before and after our “last universal common ancestor.” • The last universal common ancestor is the single life form that branched into everything since. • Earth four billion years …

Nov 14, 2024 | science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Christina V. Theodoris

PerspectiveSynthetic BiologyA genomic foundation model broadly enables sequence modeling, prediction, and designAbstractWith a vocabulary of just four nucleotides, the language of DNA encodes the fundamental information needed to orchestrate all layers of regulation in a cell, from DNA to RNA and proteins. These instructions direct the function of each cell and transmit information between generations.