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Nov 19, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |J. G. Muir
Editor’s summaryPsychedelics have been recently shown to have therapeutic potential for treating psychiatric conditions. Muir et al. performed single-nucleus RNA sequencing in psychedelic-activated neurons in mouse medial prefrontal cortex. The psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5HT2A receptor agonist with anxiolytic-like effects in mice, activated a specific subset of neurons in this brain region.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Rachel C. Rohde
Editor’s summaryAdsorption of CO2 by aqueous amines for carbon capture applications usually requires cooling of effluent gases to near-ambient temperatures. Rohde et al. found that zinc hydride sites in a metal-organic framework enabled the rapid capture of CO2 from high-temperature power generation and industrial processes (see the Perspective by Li and Zhao). Adsorption of CO2 to form zinc formate occurs reversibly through insertion into terminal zinc hydride sites.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Yu Yang
Editor’s summaryControlling and manipulating the quantum states of mechanical systems offers opportunities for developing enhanced sensing applications. Yang et al. describe the operation of a mechanical qubit enabled by a strong nonlinear interaction between phonons in a mechanical resonator (see the Perspective by Pistolesi).
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Eric Nguyen
Editor’s summaryLarge language models have great potential to interpret biological sequence data. Nguyen et al. present Evo, a multimodal artificial intelligence model that can interpret and generate genomic sequences at a vast scale. The Evo architecture leverages deep learning techniques, enabling it to process long sequences efficiently.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Peter Stern
Neuroscience Visualizing human glymphatic pathwaysPeter SternContrast dye confirms the presence of a glymphatic pathway in humans that is involved in circulating cerebrospinal fluid. PHOTO: E. YAMAMOTO ET AL., PROC. NATL. ACAD. SCI. U.S.A. (2024) 121 (42) E2407246121/CC BY-NC-NDExperiments in rodents have shown cerebrospinal fluid tracer flow through the subarachnoid space and into brain parenchyma along periarterial spaces.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Christina V. Theodoris
PerspectiveSynthetic BiologyA genomic foundation model broadly enables sequence modeling, prediction, and designAbstractWith a vocabulary of just four nucleotides, the language of DNA encodes the fundamental information needed to orchestrate all layers of regulation in a cell, from DNA to RNA and proteins. These instructions direct the function of each cell and transmit information between generations.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Dan Zhao
AbstractCarbon capture and sequestration can help limit carbon dioxide (CO2) emissions and maintain the annual global temperature increase to below 1.5? to 2°C above preindustrial levels, a goal set by the 2015 Paris Agreement (1). Sorbents—porous materials that capture a specific liquid or gas—play a role in achieving this. However, the existing technology only adsorbs CO2 at low temperatures and is not suitable for removing CO2 from hot gas streams emitted by industrial plants.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Paul Brown
Information & AuthorsInformationPublished In ScienceVolume 386 | Issue 672315 November 2024CopyrightCopyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versionsSubmission historyPublished in print: 15 November 2024PermissionsRequest permissions for this article. AcknowledgmentsThe authors thank D. G. Strauss and D. L.
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Nov 14, 2024 | 
science.org | Junhua Lyu |BaoJun Yang |Xinglin Yang |Jarrod Shilts
Cells are the building blocks of life. Yet over the course of our lives, most of the cells we have today will die and be replaced with new cells. What enables our bodies’ cohesion to go on uninterrupted even as the cellular pieces that make us are constantly changing? The answer may lie in the connections between cells.
