Christopher A Hunter

Jan 13, 2025 | pubs.acs.org | Peter Bolgar |Mohit Dhiman |Diego Núñez-Villanueva |Christopher A Hunter

1. IntroductionClick to copy section linkSection link copied!Template-directed synthesis is the basis of DNA replication and governs the transmission of biological inheritance and the expression and regulation of biological function in nature. (1,2) Soon after the discovery of the structure of DNA and the mechanism of DNA replication, Todd envisaged that chemists would emulate nature and use the principles of template-directed synthesis in organic chemistry.

Sep 25, 2024 | pubs.rsc.org | Fergal E. Hanna |Lensfield Road |Christopher A Hunter

Polarisation effects on the H-bond acceptor properties of sulfonamides† The strengths of H-bonding interactions in networks are affected by cooperativity between the interacting sites. Compounds with an intramolecular H-bond between a sulfonamide NH group and pyridine nitrogen were used to measure the magnitude of cooperative effects on intermolecular H-bonding interactions with the sulfonamide oxygen.

Aug 29, 2024 | pubs.rsc.org | Daniil O. Soloviev |Lensfield Road |Christopher A Hunter

Musketeer: a software tool for the analysis of titration data† Musketeer is a powerful open-source software tool for the analysis of titration data, featuring a simple cross-platform graphical interface for importing data directly from UV-vis, fluorescence and NMR spectrometers, or from spreadsheets.

Mar 27, 2024 | pubs.rsc.org | Mohit Dhiman |Lensfield Road |Rafel Cabot |Christopher A Hunter

Efficient automated solid-phase synthesis of recognition-encoded melamine oligomers† Recognition-encoded melamine oligomers (REMO) are synthetic polymers with an alternating 1,3,5-triazine-piperazine backbone and side chains equipped with either a phenol or phosphine oxide recognition unit. Here, we describe an automated method for highly efficient solid-phase synthesis (SPS) of REMO of any specified length and sequence.

Dec 20, 2023 | pubs.rsc.org | Timothy S. Chisholm |Lensfield Road |Christopher A Hunter

A closer look at amyloid ligands, and what they tell us about protein aggregates† The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or radiolabelled ligands is one strategy for diagnosing and better understanding these diseases. A vast number of amyloid-binding ligands have been reported in the literature as a result.