Christopher Foley

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Articles

Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B

Sep 30, 2024 | dx.doi.org | Kevin Schofield |Christopher Foley
Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank - Nature Communications

Aug 26, 2024 | nature.com | Robert F. Hillary |Riccardo E Marioni |Christopher Foley

AbstractUnderstanding how gene-environment interactions (GEIs) influence the circulating proteome could aid in biomarker discovery and validation. The presence of GEIs can be inferred from single nucleotide polymorphisms that associate with phenotypic variability - termed variance quantitative trait loci (vQTLs). Here, vQTL association studies are performed on plasma levels of 1463 proteins in 52,363 UK Biobank participants. A set of 677 independent vQTLs are identified across 568 proteins.

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