Robert F. Hillary

Aug 28, 2024 | nature.com | Jiantao Chen |Zhijian Yang |Ranran Zhai |Xiao Feng |Ting Li |Denis Maslov | +25 more

AbstractUnderstanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.

Aug 26, 2024 | nature.com | Robert F. Hillary |Riccardo E Marioni |Christopher Foley

AbstractUnderstanding how gene-environment interactions (GEIs) influence the circulating proteome could aid in biomarker discovery and validation. The presence of GEIs can be inferred from single nucleotide polymorphisms that associate with phenotypic variability - termed variance quantitative trait loci (vQTLs). Here, vQTL association studies are performed on plasma levels of 1463 proteins in 52,363 UK Biobank participants. A set of 677 independent vQTLs are identified across 568 proteins.