Christopher Lord

1 month ago | nature.com | Christian Pilarsky |Mukhopadhyay Debabrata |Christopher Lord

AbstractPancreatic ductal adenocarcinoma (PDAC) remains the most lethal cancer. While DNA damaging agents such as platinum and PARP inhibitors have derived clinical benefits, acquired resistance invariably develops. Hence there is an urgent need for novel therapeutic strategies to overcome acquired resistance. Clinically relevant resistance in PDAC patient-derived cell lines was achieved by extended exposure to chemotherapy agents.

1 month ago | monocle.com | Christopher Lord

The hand of Jony Ive is all around us: on our desks, in our pockets, in our palms. More than any other living designer, Apple's former design chief has shaped and contoured our day-to-day experience. Yet unlike the buzzing, attention-hungry iPhone - his most earth-shaking effigy - the man himself is much less forthcoming. Interview-shy, Ive was never a fixture onstage during the Steve Jobs-era product launches.

2 months ago | monocle.com | Christopher Lord

Department stores can only survive if they see beyond the bottom lineAn aura of legend exists around America's mid-century department stores. The May Company in Los Angeles, for instance, had models walk around its restaurant wearing select garments and holding up a number so that diners could order an outfit directly to their tables. Today the old May Company building is a museum about films.

2 months ago | truthdig.com | Christopher Lord

Since the start of what the Kremlin calls the Special Military Operation, known everywhere else as the invasion of Ukraine, Vladimir Putin has faced a problem: the rise of thousands of military bloggers, known as voenkory, on the encrypted Telegram app, which is outside his control. Despite his dictatorial powers, Putin cares deeply about public opinion.

Jan 23, 2025 | nature.com | Fresia Pareja |Rohit Bhargava |Virginia F. Borges |Edi Brogi |Fatima Cardoso |Christine Desmedt | +16 more

AbstractSpecial histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges.