Christopher M. Rose

Aug 10, 2024 | nature.com | Pankaj Dwivedi |Trent Hinkle |Christopher M. Rose |Seth M. Tomchik |Vishva M. Dixit |Sammy Villa

AbstractRibosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free 40 S ribosome in vivo in Drosophila. Coimmunoprecipitation and enrichment of monoubiquitinated proteins from catalytically inactive OTUD6 flies reveal RPS7 as the ribosomal substrate.

Mar 2, 2023 | nature.com | Hayley M Bennett |Christopher M. Rose

AbstractIn the last decade, single-cell RNA sequencing routinely performed on large numbers of single cells has greatly advanced our understanding of the underlying heterogeneity of complex biological systems. Technological advances have also enabled protein measurements, further contributing to the elucidation of cell types and states present in complex tissues.

Mar 2, 2023 | nature.com | Laurent Gatto |Ruedi Aebersold |Juergen Cox |Vadim Demichev |Jason Derks |Edward Emmott | +7 more

The goal of reporting is to enable other researchers to repeat, reproduce, assess and build upon published data and their interpretation79. While reproduction and replication do not guarantee accuracy, they build trust in the analysis process through verifiability, thus strengthening confidence in the reported data and results.