Sammy Villa

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OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress - Nature Communications

Aug 10, 2024 | nature.com | Pankaj Dwivedi |Trent Hinkle |Christopher M. Rose |Seth M. Tomchik |Vishva M. Dixit |Sammy Villa

AbstractRibosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free 40 S ribosome in vivo in Drosophila. Coimmunoprecipitation and enrichment of monoubiquitinated proteins from catalytically inactive OTUD6 flies reveal RPS7 as the ribosomal substrate.

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